His team wanted to better understand how cannabinoid receptors works and how they interact with marijuana compounds. In fact, a new study found the opposite — habitual marijuana use could cause users to become less sociable than others. Previous studies established that cannabinoid receptors are primarily localized in the cell membrane. Studies have shown that marijuana can help patients feel less lonely and depressed, but that doesn’t equate to cannabis making you a social butterfly. RELATED: The Difference Between Marijuana, Hemp And Cannabis When researchers gave mice THC, the psychoactive cannabinoid in cannabis, it caused a cascade of molecular processes.